After the death of their mother, the sisters Ramona and Helga flee the feudal conditions of their home village.
Chile in the 1960s offers the two young women only a new start in the favelas of the capital Santiago. Once there, they befriend the prostitute Carmen, who takes them under her wing, and sell alcohol in the neighborhood. Over time, the three women grow together to form a kind of family.
RAMONA exemplifies an entire generation whose desire for freedom and justice drove them to the cities and culminated in the election of Salvador Allende as president.